Blog
05/01/2023
Intact Mass Screening for Covalent Compound Libraries: What and Why?
Recent publications highlight an “evolving toolbox” of techniques and technologies implemented in covalent inhibitor discovery and design. Though historically covalent compound discovery has been conducted via structure based drug design, direct covalent ligand screening of electrophilic compound libraries has been […]
02/24/2023
Affinity Selection Mass Spectrometry (ASMS): What and Why?
Affinity Selection Mass Spectrometry (ASMS) is a high throughput screening (HTS) technique for identifying small molecule test compounds based on their binding affinity to a target. Unlike traditional biochemical assays that test a compound’s functional activity, ASMS is a biophysical […]