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Biophysical proteomics assays allow for proteome-wide, label-free monitoring of ligand-induced changes in protein structure and stability, offering insights into protein-ligand interactions and modulation of biophysical properties of cellular proteins. These assays exploit the principle that compound-induced alterations in structure or stability of proteins can be detected through changes in their susceptibility to denaturation. Here, we introduce solvent proteome profiling in cells (SPICE), which employs solvent-based denaturation of proteins under otherwise physiological conditions in...

The emergence of drug resistance to nearly all antimalarials following their rollout underscores the need for novel...

For a summary of this article's highlights, check out our blog post! Mutations that activate the small GTPase KRAS...

The limited understanding of the mechanism of action (MoA) of several antimalarials and the rise of drug resistance...

Antimicrobial resistance (AMR) poses a serious threat to global health. The rapid emergence of resistance contrasts...

The methyl-d-erythritol phosphate (MEP) pathway has emerged as an interesting target in the fight against antimicrobial...

Myeloid-derived suppressor cells (MDSC) are a heterogeneous cell population of incompletely differentiated immune...

Although most cancer drugs modulate the activities of cellular pathways by changing post-translational modifications...

Several inhibitors of androgen receptor (AR) function are approved for prostate cancer treatment, and their impact on...

DNA-binding proteins are promising therapeutic targets but are notoriously difficult to drug. Here, we evaluate a...