Oligo Analysis

Mass Spectrometry Services for High-Throughput Oligo Analysis and Modification Mapping with Rapid Turnaround

Momentum has extensive experience in the analysis of oligos by mass spectrometry, enabling a range of services with industry-leading turnaround time. By leveraging high-throughput sample preparation, multiple dedicated high-resolution LC-MS instruments, and automated data analysis software, our assays can measure over 5,000 samples a day, giving clients the answers they need to advance their research programs.

Our quantification and analysis services can be applied to a wide range of oligos, enabling their effective characterization. We routinely work with RNA/DNA oligos that are heavily modified and/or >100 nucleotides in length. In particular, we can perform adduct mapping via sequencing to identify site-specific modifications of DNA and RNA species. Our services are readily scalable, enabling high-throughput oligo analysis with rapid turnaround.

Oligo Analysis Services

Mass Determination

Determine the mass of the predominant oligo in a sample

Purity Analysis

Assess the purity of a target oligo

Impurities Analysis

Assess the purity of a target oligo and ascertain the chemical identities of observed impurities

Targeted Component Measurement

Quantify the abundance of target oligos in a sample, including RNA cap and tail analyses

Covalent Modification

Detect and characterize covalent modification(s) of an oligo after treatment with a target compound, including number of modifications and the amount of each modification

Sequencing

Rapid turnaround times ensure you get the answers you need quickly to advance your research program

Related Applications

Oligonucleotide Therapeutics
Gene Therapies

Explore Other Services

We offer a broad range of services to support all phases of drug discovery and development.

Data Products
Access proprietary high-quality proteomic databases – no experiments necessary
Affinity Selection Mass Spectrometry
Discover and characterize non-covalent leads with affinity selection mass spectrometry (ASMS)
Covalent Binding Assays
Identify, validate, and prioritize covalent therapeutics with Intact MS and peptide mapping
Proteomics & Chemoproteomics
Interrogate protein abundance, activity, and interactions on a global scale
Small Molecule Analysis
Quantify biomarkers, metals, and more with HPLC-MS, RapidFire-MS, and ICP-MS