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RapidFire-MS

Ultra-fast, label-free functional screening and analysis

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Our core scientific team invented the RapidFire Mass Spectrometry (RapidFire-MS) platform over 20 years ago, and they continue to serve as experts in RapidFire analytical method development and biochemical assay development. RapidFire-MS is a powerful functional assay platform that enables high-throughput, ultra-fast, automated, and label-free screening and analysis. While this technology is most widely known for high-throughput functional screening of samples and compounds in vitro, it is also well-suited for the analysis of cell samples, tissues, biofluids, and other mixed biological samples. By overcoming critical limitations associated with traditional LC-MS (such as long analysis times), RapidFire-MS empowers researchers to accelerate their drug discovery workflows.

Momentum’s scientists have contributed to over 100 peer-reviewed publications leveraging the RapidFire-MS system for drug discovery, proteomics, metabolomics, and more.

Benefits of RapidFire-MS

High Throughput

Scalable technology to support large-scale screening and analysis efforts

Ultra-Fast

Capacity to generate 10,000 datapoints per day

Automated

Reproducible sample processing to ensure high-quality results

Label Free

Biologically relevant conditions without the need for tags or labels

Broad Compatibility

Suitable for in vitro samples as well as complex biological samples of virtually any type

Expert Support

Unmatched experimental support from the inventors of the platform

Frequently Asked Questions

What kind of samples can be analyzed by RapidFire-MS?

While RapidFire-MS is most widely known for high-throughput functional screening of samples and compounds in vitro, it is also well-suited for the analysis of cell samples, tissues, biofluids, and other mixed biological samples.

Why is Momentum the right fit as a CRO partner for RapidFire-MS experiments?

Our scientists invented and commercialized the RapidFire-MS system ~20 years ago, which means that there's no better team to deliver the data you need to advance your drug discovery research. In fact, our scientists have contributed to over 100 peer-reviewed publications leveraging the RapidFire-MS system for drug discovery, proteomics, metabolomics, and more.

What are the benefits or RapidFire-MS compared to traditional LC/MS?

RapidFire-MS was specifically developed to meet the demands of the pharmaceutical industry for faster and more efficient drug screening technologies. In particular, RapidFire-MS overcomes the long chromatographic times associated with traditional LC/MS, with an average cycle time of 8 seconds (compared to many minutes for traditional approaches). This significant improvement in throughput is achieved by faster sampling, shorter flow paths, and bind/elute cleanup (instead of chromatographic separation).

How many data points can be generated per day with RapidFire-MS?

Our RapidFire-MS workflows can generate 10,000 data points in a working day and up to 40,000 using BLAZE-mode.

Explore Other Platforms

Our instrumentation enables the analysis of diverse sample types for many applications.

  • ICP-MS

    Quantitative analysis of trace and ultra-trace elements

  • Orbitrap Astral Zoom

    Cutting-edge MS technology for unmatched analysis

  • Orbitrap Ascend

    A flexible platform for rapid and accurate sample analysis

Submit a Project Inquiry

To connect with our scientific team, submit a project inquiry. Our team will be in touch shortly to schedule an introductory meeting.

Locations

United States

3 Federal Street, Suite 300
Billerica, MA 01821

Europe

Lise-Meitner-Strasse 30,
85354 Freising, Germany

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