Proteomics & Chemoproteomics Services - Momentum Biotechnologies

Our Proteomic & Chemoproteomic Services

We offer an extensive collection of proteomics and chemoproteomics services that harness the quantitative power of mass spectrometry to deliver actionable biological insights, including to support target identification, target deconvolution, and selectivity profiling efforts. Our flexible and scalable assay suite enables the system-wide interrogation of protein abundance, turnover, modifications, interactions, and localization across a wide variety of sample types, taking you all the way from discovery and target identification through preclinical work and even exploratory studies of clinical samples.

Overview

Proteomics & Chemoproteomics

01.

Experimental Design

Consult with our team to develop a proteomic workflow customized to your needs

02.

Sample Preparation

Provide samples or leverage our in-house cell culture and protein production capabilities

03.

Sample Analysis

Scalable and flexible analysis of samples using mass spectrometry

04.

Data Processing & Interpretation

Receive results and insights via an in-depth data presentation by our team

Explore our extensive portfolio of proteomic & chemoproteomic services

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Benefits of Our Workflows

End-to-End Solutions

Dedicated support from cell biology through bioinformatic data analysis and expert interpretation

Comprehensive

Proteome-wide analyses enable global characterization of targets, systems, pathways, hits, and leads

Flexible

Our assays are compatible with a broad variety of sample types and can be further customized to meet your experimental needs

Scalable

Many assays are already available in high-throughput formats, and all assays can be scaled up for screening and high-throughput profiling campaigns

Quantitative

Superior quantitative accuracy powered by mass spectrometry

Fast Turnaround

Rapid turnaround times ensure you get the answers you need quickly to advance your research program

Application Highlight: Target Deconvolution

Explore our chemoproteomics services to support target deconvolution efforts:

CHIPP
CysScout™
PhotoTargetScout™
SPICE
TargetScout™

Technology Highlight: ABPP

Activity-Based Protein Profiling Services

Activity-based protein profiling (ABPP) is a powerful chemoproteomic technique that uses reactive probes to map ligandable residues across a target of interest, as well as to identify the specific targets and binding sites of a reactive compound. At Momentum, we offer ABPP services through our CysScout^TM technology, which leverages reactive cysteine probes to enable the high-throughput, proteome-wide evaluation of the cellular cysteinome. These assays can be performed as part of a covalent screening workflow or as a stand-alone experiment. In addition to CysScout^TM for ABPP, our team can work with you to develop a customized workflow for the global analysis of non-cysteine residues at scale.

Explore CysScout™

Explore Other Services

We offer a broad range of services to support all phases of drug discovery and development.

Small Molecule Analysis
Quantify biomarkers, metals, and more with HPLC-MS, RapidFire-MS, and ICP-MS
Oligo Analysis
Analyze DNA/RNA oligos with superior turnaround time
Data Products
Access proprietary high-quality proteomic databases – no experiments necessary
Affinity Selection Mass Spectrometry
Discover and characterize non-covalent leads with affinity selection mass spectrometry (ASMS)
Covalent Binding Assays
Identify, validate, and prioritize covalent therapeutics with Intact MS and peptide mapping