Lead Generation

Lead Generation

Once a target has been selected and validated, lead generation is performed to identify drug candidates, typically through large-scale screening efforts. These screens seek to discover hits that bind to the target and/or affect its activity or other key properties. We offer small-molecule screening services for both non-covalent and covalent modalities, supported by extensive in-house chemical libraries, to enable the rapid and efficient discovery of hits against a broad range of target classes. Following initial screening and hit discovery, secondary assays are performed to validate and rank-order prospective leads. In addition to evaluating their binding affinity and kinetics, follow-up experiments can explore candidate specificity, toxicity, or other critical parameters.