Molecular Glues

Comprehensive CRO services to support all steps of molecular glue development

Molecular glues are small molecules that induce novel protein-protein interactions or stabilize existing ones, ultimately leading to target degradation or inhibition. These powerful therapeutics offer significant promise for previously undruggable targets and represent an exciting horizon of therapeutic innovation. As a molecular glue CRO, we offer a suite of services to support molecular glue discovery and development throughout target selection, screening, optimization, and preclinical characterization.

Our unique molecular glue screening strategy pairs target screening (in which complex proteins are screened together to identify all binders) with counter-screening (in which individual proteins are screened in parallel to identify single-protein binders), facilitating the identification of complex-specific leads. Promising hits can then be validated and interrogated in biochemical and cell-based assays. We also offer high-throughput phenotypic screening of molecular glue degraders (as well as other targeted degrader modalities) using our ProteomeScout-HT^TM platform.