Screening Laboratory

Our laboratory facilities are designed to enable rapid and rigorous high-throughput screening.

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Our screening laboratory is based outside Boston in Billerica, Massachusetts. This site features a variety of mass spectrometers, ensuring that the ideal instrument can be used for each specific application, as well as integrated platforms for automated sample processing and compound/library management. These capabilities are essential to ensure that large-scale, high-throughput screens can be performed rapidly, reproducibly, and methodically. Beyond our instrumentation and organization, our screening services are supported by an expert scientific team. Our core team of scientists and engineers have been serving clients with mass spectrometry-based services for over twenty years, giving them deep experience with a diverse array of applications and the ability to successfully solve challenging problems for our clients.

As a CRO specializing in mass spectrometry for high-throughput screening and proteomics, these screening capabilities drive our ability to support research teams through the drug discovery process. We specialize in label-free high-throughput screening approaches, including ASMS (Affinity Selection Mass Spectrometry) for non-covalent screening, Intact MS for covalent screening, and RapidFire-MS for functional screening. By partnering with a knowledgeable CRO like Momentum Biotechnologies, you gain access to significant expertise in screening, follow-up, and data analysis, helping to ensure that you get accurate, physiologically relevant hits.

In addition to performing high-throughput screens, we can offer support for compound management across in-house libraries, client libraries, and third-party libraries. We leverage cutting-edge technology in combination with purpose-built computational workflows to enable effective screening of chemical libraries of virtually any size and type.

Frequently Asked Questions

What screening services does Momentum Biotechnologies offer?

Momentum Biotechnologies offers a wide range of mass spectrometry-based CRO services for high-throughput screening. For traditional label-free screening of small-molecule libraries, we offer Affinity Selection Mass Spectrometry for non-covalent compounds and Intact MS screening for covalent compounds. For functional enzyme screening, we offer the RapidFire-MS screening platform. For clients interested in phenotypic screening, we can provide high-throughput proteome profiling using the ProteomeScout-HT platform. Finally, our CHIPP target deconvolution platform is a powerful approach for proteome-wide screening of drug-target interactions. If we don't offer your desired screening workflow as an off-the-shelf service, our team is happy to collaborate on a bespoke solution to your specific experimental needs.

What instrumentation does Momentum use for screening?

We operate a broad range of mass spectrometers and supporting instrumentation to power our screening workflows. Our US site operates 12 x RapidFire systems, Agilent 1260 HPLC + 1290 UHPLC’s, 10 x Sciex API4000 QqQ MS, 11 x Agilent 6230B ToF , Agilent QToF MS (6540/6545/2x6545XT/ 2x6550), Agilent 8800 ICP-MS, 2 x Thermo Orbitrap Ascend, and an Echo Acoustic Liquid Handler with Access Workstation for compound management. Our EU site features of variety of mass spec instruments, including multiple Astral Zooms.

Explore Other Areas of Expertise

Our services are supported by deep expertise in a range of areas.

  • Biochemistry & Chemical Biology

  • Cell & Molecular Biology

  • MS-based Proteomics

  • Computational Biology

  • Project Management

  • Compound Management & Chemical Libraries

Submit a Project Inquiry

To connect with our scientific team, submit a project inquiry. Our team will be in touch shortly to schedule an introductory meeting.

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