CHIPP

Chaotrope-induced protein precipitation & proteome profiling (CHIPP) is a readily scalable, label-free assay for the study of drug:target interactions. This novel technology, developed in-house by the scientific team at Momentum Biotechnologies, leverages isothermal, reversible chemical denaturation of proteins to enable sensitive drug target identification under near-physiological conditions with proteome-wide readout (>8,000 proteins). Magnetic particle-based precipitation facilitates increased experimental throughput (96-well plate format) and is compatible with a wide range of downstream workflows.

This robust and automated approach is well-suited for use as a front-line validation assay for primary screening hits, enabling the systematic analysis of drugs and compounds in a fast and reliable way. CHIPP demonstrates a high success rate for target identification across a wide range of compounds, including allosteric inhibitors, molecular glues, targeted protein degraders, and enzyme inhibitors.