Protein Turnover Atlas™

On-demand access to protein turnover data

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Cellular protein levels are determined by the interplay between protein synthesis and protein degradation. A comprehensive understanding of these dynamics in a given cell type is central to drug discovery efforts, playing a particularly crucial role in the development of new chemical modalities.

Protein Turnover Atlas™ is a curated repository of proprietary protein half-life data, including modeling of degradation rates, synthesis rates, cell proliferation, and protein copies per cell. Half-lives span from <1 hour to hundreds of hours and cover a diverse range of tissue and disease contexts, including several common cancer-related mutations. The Protein Turnover Atlas™ currently contains half-life data for ~16,000 proteins and more than 25,000 isoforms across 47 cell lines (average of >7,100 protein IDs per cell line).

Its partner database – the Mouse Turnover Atlas™ – provides in vivo turnover data derived from 20 murine tissues and 2 biofluids. This complementary resource includes ~13,500 protein half-lives and over 16,000 isoforms, with high proteome coverage for all tissues/biofluids.

Momentum also offers access to the Proteome Atlas™, a repository of proteome profiling data from >250 cell types.

By providing access to critical information about protein dynamics, these resources empower researchers to:

  • select targets and prioritize modalities
  • design experiments and assays based on known target half-lives
  • understand pharmacokinetic-pharmacodynamic (PK-PD) relationships
  • assess off-targets and their relevance
  • and more!

All of the Atlas products offer flexible access options, allowing you to choose the report type that best fits your needs.

  • Cell Line Report: proteome-wide protein turnover data for a specific cell line/tissue
  • Single Protein Report: protein-specific turnover data across all analyzed cell lines/tissues
  • Global Repository Access: all protein turnover data across all analyzed cell lines/tissues

You can explore this resource further at our dedicated Protein Turnover Atlas™ portal.

Frequently Asked Questions

How can the Atlas products advance drug discovery research?

The Atlas products provide valuable information to increase the efficiency and efficacy of screening projects and guide early-stage drug discovery research. Flexible, on-demand data options make the Atlas products accessible to a wide range of research teams, reducing the time and cost burden associated with generating comparable data in-house or through a research partner. These resources empower researchers to make informed decisions about potential targets, appropriate modalities, and other key parameters relevant to drug discovery and development.

Who can benefit from the use of Momentum's Atlas products?

These products are of broad relevance to those involved in drug discovery and development efforts, providing significant benefit to researchers seeking to evaluate novel targets and modalities. In particular, the Atlas products can benefit teams working to develop emerging therapeutic modalities, such as targeted protein degraders, molecular glues, RNA-targeting drugs, and covalent therapeutics. By using data from the Atlas products to guide preclinical research, scientists can make informed predictions about the safety and efficacy of a particular therapeutic approach early in the drug development process, saving considerable time and expense. The Atlas products also have substantial utility for data science and biological intelligence teams, as large amounts of high-quality data are required for the training and development of novel models and tools.

Can the Atlas products be used to train AI & computational models?

Momentum's Atlas products facilitate the development and training of novel computational models and other tools by data science teams seeking to leverage biological data; as these models are only as accurate as the data used in their development, the provision of high-quality, curated data through the Atlas products supports the creation of superior data science products. The information provided in the Atlas products is well-curated and easily accessible, including both HTML reports and tabular data formats, with high proteome coverage across all analyzed cell and tissue types.

Explore Other Technologies

Our technologies provide insight into protein abundance, activity, interactions, and more.

  • Proteome Atlas™

    Protein expression data across cell lines & tissues

  • ProteomeScout™

    Deep and rapid proteome profiling

  • QuantScout™

    Targeted quantification of relevant proteoforms with maximum accuracy

  • SignalingScout™

    Proteome-wide phosphorylation profiling

  • SPICE

    Label-free target profiling in cells with biophysical proteomics

  • SurfaceScout™

    Profiling of cell surface proteomes

  • TargetScout™

    Versatile, robust, and scalable platform for compound pulldowns

  • TurnoverScout™

    Global profiling of protein synthesis and degradation

  • UbiScout™

    Profiling of ubiquitination sites

  • CHIPP

    Sensitive, label-free, and scalable drug:target profiling

  • CysScout™

    Profiling of reactive cysteines

  • DecryptM

    Concentration-resolved PTM profiling

  • KinomeScout™

    Target profiling for kinases and other ATP-binding proteins

  • NucleoBeads™

    Identifying and characterizing functional inhibitors of DNA-binding proteins and transcription factors

  • PhotoTargetScout™

    Photo-affinity labeling and identification of compound-binding proteins

  • PlasmaScout™

    Clinical proteomics of plasma and serum proteins

Submit a Project Inquiry

To connect with our scientific team, submit a project inquiry. Our team will be in touch shortly to schedule an introductory meeting.

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