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Affinity Selection Mass SpectrometryAffinity Selection Mass SpectrometryCovalent Binding AssaysCovalent Binding AssaysProteomics & ChemoproteomicsProteomics & ChemoproteomicsSmall Molecule AnalysisSmall Molecule AnalysisOligo AnalysisOligo AnalysisData ProductsData ProductsView All ServicesView All Services

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Target Discovery & ValidationTarget Discovery & ValidationLead GenerationLead GenerationLead Selection & OptimizationLead Selection & OptimizationPreclinical StudiesPreclinical StudiesBiomarker Discovery, Development & AnalysisBiomarker Discovery, Development & AnalysisView All PhasesView All Phases

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RadiotherapeuticsRadiotherapeuticsMolecular GluesMolecular GluesTargeted Protein DegradersTargeted Protein DegradersCovalent DrugsCovalent DrugsDNA- and RNA-Targeting DrugsDNA- and RNA-Targeting DrugsOligonucleotide TherapeuticsOligonucleotide TherapeuticsKinase InhibitorsKinase InhibitorsView All ModalitiesView All Modalities

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CHIPPCHIPPCysScout™CysScout™DecryptMDecryptMKinomeScout™KinomeScout™NucleoBeads™NucleoBeads™PhotoTargetScout™PhotoTargetScout™PlasmaScout™PlasmaScout™Protein Turnover Atlas™Protein Turnover Atlas™Proteome Atlas™Proteome Atlas™ProteomeScout™ProteomeScout™QuantScout™QuantScout™SignalingScout™SignalingScout™SPICESPICESurfaceScout™SurfaceScout™TargetScout™TargetScout™TurnoverScout™TurnoverScout™UbiScout™UbiScout™View All TechnologiesView All Technologies

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Expertise

Compound Management & Chemical LibrariesCompound Management & Chemical LibrariesScreening LaboratoryScreening LaboratoryBiochemistry & Chemical BiologyBiochemistry & Chemical BiologyCell & Molecular BiologyCell & Molecular BiologyMS-based ProteomicsMS-based ProteomicsComputational BiologyComputational BiologyProject ManagementProject ManagementView All ExpertiseView All Areas of Expertise

Explore Our Resource Library

August 6, 2026
•Posters

Zane Thistleford, Christina Thompson, William LaMarr, Can Ozbal, Jan Kubicek & Barbara Maertens

Investigation of Hits against the GLP-1 Receptor Identified by Affinity Selection Mass Spectrometry: Hit Expansion, Structure-Activity Relationships, and Selectivity Profiling

Small molecule engagement of the GLP-1 receptor using affinity selection mass spectrometry (ASMS) proved to be a productive starting point for drug discovery, with a 50,000 compound diversity screen identifying three structurally distinct hit series that could be expanded and characterized in depth. Hit expansion across 52 analogs established clear structure-activity relationships within 3 scaffolds.

February 27, 2026
•Blog Posts

Eileen Ablondi

Native MS in Drug Discovery & Development

In this month’s blog post, we’re spotlighting one of our newest service lines – Native MS. This powerful technology is...

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