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Affinity Selection Mass SpectrometryAffinity Selection Mass SpectrometryCovalent Binding AssaysCovalent Binding AssaysProteomics & ChemoproteomicsProteomics & ChemoproteomicsSmall Molecule AnalysisSmall Molecule AnalysisOligo AnalysisOligo AnalysisData ProductsData ProductsView All ServicesView All Services

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Target Discovery & ValidationTarget Discovery & ValidationLead GenerationLead GenerationLead Selection & OptimizationLead Selection & OptimizationPreclinical StudiesPreclinical StudiesBiomarker Discovery, Development & AnalysisBiomarker Discovery, Development & AnalysisView All PhasesView All Phases

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RadiotherapeuticsRadiotherapeuticsMolecular GluesMolecular GluesTargeted Protein DegradersTargeted Protein DegradersCovalent DrugsCovalent DrugsDNA- and RNA-Targeting DrugsDNA- and RNA-Targeting DrugsOligonucleotide TherapeuticsOligonucleotide TherapeuticsKinase InhibitorsKinase InhibitorsView All ModalitiesView All Modalities

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OncologyOncologyImmunologyImmunologyNeuroscienceNeuroscienceMetabolic DiseaseMetabolic DiseaseInfectious DiseaseInfectious DiseaseRare DiseasesRare DiseasesView All Therapeutic AreasView All Therapeutic Areas

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CHIPPCHIPPCysScout™CysScout™DecryptMDecryptMKinomeScout™KinomeScout™NucleoBeads™NucleoBeads™PhotoTargetScout™PhotoTargetScout™PlasmaScout™PlasmaScout™Protein Turnover Atlas™Protein Turnover Atlas™Proteome Atlas™Proteome Atlas™ProteomeScout™ProteomeScout™QuantScout™QuantScout™SignalingScout™SignalingScout™SPICESPICESurfaceScout™SurfaceScout™TargetScout™TargetScout™TurnoverScout™TurnoverScout™UbiScout™UbiScout™View All TechnologiesView All Technologies

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RapidFire-MSRapidFire-MSICP-MSICP-MSOrbitrap Astral ZoomOrbitrap Astral ZoomOrbitrap AscendOrbitrap AscendView All PlatformsView All Platforms

Expertise

Compound Management & Chemical LibrariesCompound Management & Chemical LibrariesScreening LaboratoryScreening LaboratoryBiochemistry & Chemical BiologyBiochemistry & Chemical BiologyCell & Molecular BiologyCell & Molecular BiologyMS-based ProteomicsMS-based ProteomicsComputational BiologyComputational BiologyProject ManagementProject ManagementView All ExpertiseView All Areas of Expertise

Explore Our Resource Library

October 30, 2026
•Blog Posts

Eileen Ablondi, PhD

High-Throughput Screening Services for Molecular Glues & Degraders

Targeted protein degraders, molecular glues, and other induced-proximity modalities have significant potential to expand the pharmaceutical toolbox, enabling previously undruggable proteins to be readily targeted for therapeutic intervention. However, the discovery and development of these powerful modalities pose distinct challenges to researchers. One way that teams can accelerate research timelines is by partnering with specialized CROs like Momentum Biotechnologies, who have specific expertise in high-throughput screening techniques relevant to TPD and glue discovery. These CROs have...

August 6, 2026
•Posters

Zane Thistleford, Christina Thompson, William LaMarr, Can Ozbal, Jan Kubicek & Barbara Maertens

Investigation of Hits against the GLP-1 Receptor Identified by Affinity Selection Mass Spectrometry: Hit Expansion, Structure-Activity Relationships, and Selectivity Profiling

Small molecule engagement of the GLP-1 receptor using affinity selection mass spectrometry (ASMS) proved to be a productive starting point for drug discovery, with a 50,000 compound diversity screen identifying three structurally distinct hit series that could be expanded and characterized in depth. Hit expansion across 52 analogs established clear structure-activity relationships within 3 scaffolds.

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