Native molecule binding assays using Affinity Selection Mass Spectrometry

Momentum Biotechnologies and Axxam have recently joined forces to combine the AXXDiversity small molecule library with Momentum’s Affinity Ligand Identification System (ALIS) as a new native molecule binding assay and screening option for our clients. The platform enables identification of small molecule binders to protein or nucleic acid targets. This field is continuously gaining relevance in the context of bifunctional degraders, molecular glues, RNA targets, and protein-protein interactions.

The webinar will briefly describe main features of the Axxam compound library and introduce Momentum’s ALIS and its underlying simple, automated, and high-throughput workflow utilizing Affinity Selection Mass Spectroscopy (ASMS). Advantages of this methodology over other drug target binding assay methods / native molecule binding assay methods include minimal target quantity and assay development requirements, protocol flexibility, and target versatility. Primary hits are immediately identified and available for further validation and follow-up studies, for which Axxam can add further assay biology and early medicinal chemistry support.