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Preserving the native phenotype of primary cells in vitro is a complex challenge. Recently, hydrogel-based cellular matrices have evolved as alternatives to conventional cell culture techniques. We developed a bacterial cellulose-based aqueous gel-like biomaterial, dubbed Xellulin, which mimics a cellular microenvironment and seems to maintain the native phenotype of cultured and primary cells. When applied to human umbilical vein endothelial cells (HUVEC), it allowed the continuous cultivation of cell monolayers for more than one year without degradation or dedifferentiation. To investigate...

The bottom-up proteomic analysis of cell line and tissue samples to a depth > 10,000 proteins still represents a...

Liquid chromatography coupled online to nano-electrospray ionization (nESI) tandem mass spectrometry is the analytical...