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Despite their importance in determining protein abundance, a comprehensive catalogue of sequence features controlling protein‐to‐mRNA (PTR) ratios and a quantification of their effects are still lacking. Here, we quantified PTR ratios for 11,575 proteins across 29 human tissues using matched transcriptomes and proteomes. We estimated by regression the contribution of known sequence determinants of protein synthesis and degradation in addition to 45 mRNA and 3 protein sequence motifs that we found by association testing. While PTR ratios span more than 2 orders of magnitude, our integrative...

Citrullination is a posttranslational modification of arginine catalyzed by five peptidylarginine deiminases (PADs) in...

The pig is one of the earliest domesticated animals in the history of human civilization and represents one of the most...

Preserving the native phenotype of primary cells in vitro is a complex challenge. Recently, hydrogel-based cellular...

The bottom-up proteomic analysis of cell line and tissue samples to a depth > 10,000 proteins still represents a...

Liquid chromatography coupled online to nano-electrospray ionization (nESI) tandem mass spectrometry is the analytical...