Gene Therapies

Support for the development and validation of gene therapies

Gene therapy is a transformative therapeutic paradigm in which genetic content is introduced, replaced, or modified for the treatment of genetic disease. For diseases associated with gene mutations, a functional copy of the gene can be provided to rescue protein production. In other contexts, genes can be edited to correct deleterious mutations or inhibited to prevent transcription or translation of aberrant content. Momentum can provide services to support many aspects of gene therapy development, validating the efficacy and specificity of treatments to drive clinical innovation.

Our experience in cell culture and gene delivery platforms (including AAV and lentiviral systems) allows us to facilitate gene therapy research. Depending on the gene therapy target, a range of proteomic approaches can be employed to validate the restoration of physiologically normal protein interaction networks, subcellular distributions, post-translational modifications, and cellular signalling pathways following treatment, enabling the mechanistic demonstration of functional efficacy.