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What is targeted quantitative proteomics? Targeted quantitative proteomics is a powerful approach to biochemical characterization that leverages mass spectrometry to detect and quantify up to one hundred proteins of interest from complex biological samples with high sensitivity and accuracy. This technique can be applied in high throughput across multiplexed samples representing different cell lines, patient samples, etc., to enable quantification of clinically relevant proteins. Targeted quantitative proteomics unites the broad scope of untargeted global proteomics with the superior...

What is protein turnover? Protein levels within a cell are not fixed and invariant. Rather, they represent the net...

How are splicing modulators used therapeutically? As the world of small-molecule therapeutics continues to expand,...

What are microRNAs (miRNAs)? MicroRNAs (miRNAs) are a class of short noncoding RNAs that modulate gene expression...

Since January 2024, 46 novel drugs have been approved by the U.S. Food and Drug Administration (FDA), with roughly half...

What is ICP-MS? Inductively coupled plasma mass spectrometry (ICP-MS) is a powerful technique for the trace and...

Covalent drugs and degraders, defined by their ability to form covalent bonds with their targets, represent a powerful...